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目的:探讨女性系统性红斑狼疮患者血清瘦素与性激素水平的变化及意义。方法:采用放射免疫分析法对42例女性系统性红斑狼疮患者及30例正常对照组血清瘦素和性激素水平进行检测。结果:女性系统性红斑狼疮患者血清瘦素和雌二醇水平明显高于正常对照组(P<0.01),睾酮明显低于对照组(P<0.01),血清瘦素水平与睾酮水平呈负相关(r=-0.63),与雌二醇水平呈正相关。结论:女性系统性红斑狼疮患者血清瘦素与性激素水平的变化相关,瘦素可能参与女性系统性红斑狼疮发病。
Objective: To investigate the changes of serum leptin and sex hormone in patients with systemic lupus erythematosus (SLE) and its significance. Methods: Serum leptin and sex hormone levels were measured in 42 women with systemic lupus erythematosus and 30 normal controls by radioimmunoassay. Results: Serum leptin and estradiol levels were significantly higher in women with systemic lupus erythematosus than those in normal controls (P <0.01), testosterone levels were significantly lower in patients with systemic lupus erythematosus (P <0.01), serum leptin level was negatively correlated with testosterone (r = -0.63), which was positively correlated with estradiol level. Conclusion: Serum leptin levels in female patients with systemic lupus erythematosus correlate with changes in sex hormone levels. Leptin may be involved in the pathogenesis of systemic lupus erythematosus in women.