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血小板是动脉血栓形成的必需成分。当胶元直接暴露于动脉内腔,血小板就迅速地粘着在上面,并释放活性物质,主要是二磷酸腺苷;二磷酸腺苷又引起其他血小板又在创面上聚集;这种聚集起来的血小板又释放出聚集物质,从而成为自发的持续性变化。特别在血栓形成的后期,虽然有一定程度的凝血,而在动脉血栓形成的早期血小板起着重要的作用。动脉血栓系在急速的血流中形成。在它们的形成过程中,难免有许多血小板凝块被冲脱而成为微型栓子(microembolus)带到末梢。在有冠状动脉血栓形成的一切症状而死亡的病人中,有一大部分在尸体时未能发现新鲜的血栓。Robert温习了28篇急性心肌梗塞尸解3409例的报导,仅57%的病例在冠状动脉内有急性血栓形成。Spain和Brodess分析在302例的分析中,认为症状的出现与死亡的时间间隔越长,则找见新鲜血栓的可能性也越大。由此,我们完全有理由推测这种微型栓子对于急性心肌梗死的发病和死亡起着显著的作用,可能此种机制亦与“小中风”有关。(Small stroke)假如能抑制血小板的聚集,则有理由推测可以减少动脉的血栓形成和栓子脱落;进而也有理由相信动脉粥样硬化本身的病变也能得到改善。虽然动脉粥样硬化的病因不明,但毫无疑问,在
Platelets are an essential component of arterial thrombosis. When the glue element is exposed directly to the lumen of the artery, the platelets rapidly adhere to it and release the active substance, mainly adenosine diphosphate; adenosine diphosphate in turn causes other platelets to accumulate again on the wound surface; this aggregated platelet It also releases aggregated matter and becomes a spontaneous, persistent change. Especially in the late stages of thrombosis, although there is a degree of coagulation, early platelets play an important role in arterial thrombosis. Arterial thrombus forms in rapid blood flow. During their formation, it is inevitable that many platelet clots have been stripped to become micro-emboli to the distal end. A significant proportion of patients who died of all the symptoms of coronary thrombosis did not find fresh blood clots at the time of their death. Robert reviewed 3409 cases of autopsy of 28 patients with acute myocardial infarction reported that only 57% of cases had acute thrombosis in the coronary arteries. Analysis of Spain and Brodess In the analysis of 302 patients, the longer the interval between the appearance of symptoms and death, the greater the possibility of finding a fresh thrombus. From this we have every reason to speculate that such mini-emboli play a significant role in the pathogenesis and mortality of acute myocardial infarction and may be related to “small stroke.” (Small stroke) If the inhibition of platelet aggregation, there is reason to speculate that can reduce arterial thrombosis and emboli off; and then there is reason to believe that atherosclerosis itself lesions can be improved. Although the etiology of atherosclerosis is unknown, there is no doubt that at