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目的：观察内皮素（ET）、降钙素基因相关肽（CGRP）、内源性类洋地黄物质（EDLS）对肾综合征出血热（HFRS）患者心、肾功能的影响。方法：用放免法（RIA）检测血浆ET、CGRP、EDLS，全自动生化仪检测血尿素氮（BUN）、肌酸磷酸激酶（CPK），给12例患者作了多巴胺激发试验。结果：病程各期见血浆ET升高，CGRP降低，ET／CGRP比值显著上升，且ET／CGRP变化曲线与BUN、CPK之变化趋势大体一致。经多巴胺激发后血浆CGRP较基础值升高十余倍，而ET变化不大。血清EDLS于发热期稍有下降，低血压、少尿期则下降明显，重症组较轻症组下降更著。与此同时心电图大多呈现心肌损害的异常波型如心律失常、Q－T间期延长、低电压、Ⅰ°与Ⅱ°房室传导阻滞、ST－T波改变等；而轻症患者较少出现上述异常。结论：HFRS病程中血浆ET升高、CGRP与EDLS减低是引起心、肾功能损害的重要因素之一，表明体液因子的变化也参与HFRS的发病过程。
Objective: To observe the effects of endothelin (ET), calcitonin gene related peptide (CGRP) and endogenous digitalisolide (EDLS) on heart and kidney function in patients with hemorrhagic fever with renal syndrome (HFRS). Methods: ET, CGRP and EDLS were detected by radioimmunoassay (RIA), BUN and CPK were detected by automatic biochemical analyzer. The dopamine challenge test was performed in 12 patients. Results: During the course of the disease, the plasma ET increased, the CGRP decreased, the ET / CGRP ratio increased significantly, and the trend of ET / CGRP curve was consistent with that of BUN and CPK. After dopamine challenge plasma CGRP increased more than ten times the base value, while ET little change. Serum EDLS slightly decreased in the fever period, hypotension, oliguria decreased significantly, more severe cases of mild group decreased more. At the same time, most of the electrocardiogram showed abnormal wave patterns of myocardial damage such as arrhythmia, Q-T prolongation, low voltage, Ⅰ ° and Ⅱ ° atrioventricular block, ST-T wave changes; The above exception occurs. Conclusion: Elevated plasma ET, decreased CGRP and EDLS during HFRS are one of the important factors that cause cardiac and renal dysfunction, indicating that the changes of humoral factors are also involved in the pathogenesis of HFRS.