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胆汁的pH条件下(pH=6～8),应该生成无定形磷酸钙(ACP),而在胆结石中磷酸钙通常以羟基磷灰石的形式出现.利用谱学方法研究了ACP与胆盐的作用.结果表明,胆盐以胶团的形式与ACP作用,在溶液中形成复合胶团,使其溶解度增加.不同类型胆盐与ACP的作用能力不同:脱氧胆酸钠(NaDC)>牛磺胆酸钠(NaTC)>胆酸钠(NaC).胆盐与ACP中HPO2-4结合钙的亲和能力大于PO3-4结合钙的亲和能力,使ACP在胆汁的环境下容易转化为羟基磷灰石.
In the case of bile pH (pH = 6 ~ 8), amorphous calcium phosphate (ACP) should be formed, while in calcium gallstones, calcium phosphate usually appears in the form of hydroxyapatite.According to spectroscopic methods, The results showed that the bile salts form micelles with ACP to form complex micelles in solution to increase the solubility of bile salts.Different types of bile salts have different ability to act on ACP: sodium deoxycholate (NaDC)> cow NaTC> NaC. The affinity of bile salts with HPO2-4-bound calcium in ACP is greater than that of PO3-4-bound calcium, rendering ACP readily convertible in the bile environment to Hydroxyapatite.