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目的:探讨血清前S1抗原(pre-S1Ag)在乙肝阳性患者中的利用价值及临床意义。方法:采用ELISA法对2 041例各型乙型肝炎患者进行血清前S1抗原(pre-S1Ag)检测。结果:前S1抗原在HBe Ag阳性标本中检出率为76.64%,明显高于其在HBe Ag阴性标本中的比例45.92%,说明前S1抗原与具有病毒活动性复制指标HBe Ag存在一定的关系,可做为一项重要的补充指标。结论:对乙肝患者进行病毒前S1抗原检测有助于临床诊断、疗效观察及预后判断。
Objective: To investigate the value and clinical significance of pre-S1Ag in patients with hepatitis B positive. Methods: Serum pre-S1 antigen (pre-S1Ag) was detected in 2041 hepatitis B patients by ELISA. Results: The positive rate of pre-S1 antigen was 76.64% in HBeAg-positive samples, which was significantly higher than that in HBeAg-negative samples (45.92%), indicating that there was a relationship between pre-S1 antigen and HBeAg , Can be used as an important supplementary indicator. Conclusion: The detection of HBV PreS1 antigen in hepatitis B patients is helpful for clinical diagnosis, curative effect observation and prognosis judgment.