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目的:研究有氧运动对二甲基苯蒽(DMBA)诱导大鼠乳腺癌发生的影响并探讨其可能的机制。方法:将120只8周龄雌性Sprague-Dawley(SD)大鼠随机分为空白对照组(CON)、运动对照组(ECON)、药物诱导组(DI)和运动+药物诱导组(EDI),每组30只。ECON组和EDI组进行有氧运动训练,运动强度为25 m/min,30 min/d,每周5天。DI组和EDI组分别给予1 ml 10 mg/ml的DMBA麻油溶液灌胃2次。每2周记录1次大鼠的体重、荷瘤数和乳腺肿瘤体。18周后处死所有大鼠,对大鼠乳房肿瘤进行病理诊断,处死大鼠前测定血清TNF-а、IL-6、CRP和sE-selectin水平。结果:实验结束时ECON组体重为(353.8±31.13)g,CON组体重为(325.7±28.52)g,两组相比体重明显下降,差异有统计学意义,P<0.05。DI组体重为(299.2±29.28)g,EDI组体重为(294.3±25.96)g,两组间比较,差异无统计学意义,P>0.05。DI组诱发乳腺癌概率(30/30)显著高于EDI组(24/30),两组之间比较,差异有统计学意义,P<0.05。DI组的潜伏期为(13.83±2.83)天,EDI组的潜伏期为(15.58±2.21)天,组间差异有统计学意义(P<0.05)。DI组的荷瘤数为3.03±1.16,EDI组的荷瘤数为2.21±1.06,组间比较,差异有统计学意义(P<0.05)。DI组的肿瘤体积为(2 185.03±528.21)mm3,EDI组的肿瘤体积为(1 763.08±519.44)mm3,组间比较,差异有统计学意义(P<0.05)。ECON组与CON组相比及EDI组与DI组相比,TNF-а、CRP、sE-selectin水平显著降低,血清IL-6水平显著升高,差异均有统计学意义(P<0.05)。结论:有氧运动可以抑制DMBA诱导大鼠乳腺癌的发生,降低全身慢性炎症水平可能是其作用机制之一。
Objective: To investigate the effect of aerobic exercise on the development of breast cancer induced by dimethylbenzyl anthracene (DMBA) in rats and its possible mechanism. Methods: 120 Sprague-Dawley (SD) rats of 8 weeks old were randomly divided into control group (CON), exercise control group (ECON), drug-induced group (DI) and exercise plus drug-induced group Each group of 30. ECON group and EDI group were trained in aerobic exercise with exercise intensity of 25 m / min for 30 min / d and 5 days a week. DI group and EDI group were given 1 ml of 10 mg / ml DMBA sesame oil solution 2 times. Rats were recorded every 2 weeks the body weight, tumor number and breast tumor body. After 18 weeks, all the rats were sacrificed and pathological diagnosis was made on the mammary tumor in rats. The levels of TNF-а, IL-6, CRP and sE-selectin in serum were determined before sacrifice. Results: At the end of the experiment, the body weight of ECON group was (353.8 ± 31.13) g, and the body weight of CON group was (325.7 ± 28.52) g. There was significant difference between the two groups (P <0.05). The body weight of DI group was (299.2 ± 29.28) g and that of EDI group was (294.3 ± 25.96) g. There was no significant difference between the two groups (P> 0.05). The probability of breast cancer induced by DI group (30/30) was significantly higher than that of EDI group (24/30). There was significant difference between the two groups (P <0.05). The latency of DI group was (13.83 ± 2.83) days, while that of EDI group was (15.58 ± 2.21) days. The difference between the two groups was statistically significant (P <0.05). The number of tumor-bearing in DI group was 3.03 ± 1.16, and the number of tumor-bearing in EDI group was 2.21 ± 1.06. The difference between the two groups was statistically significant (P <0.05). The tumor volume of DI group was (2 185.03 ± 528.21) mm3, while that of EDI group was (1 763.08 ± 519.44) mm3. There was significant difference between groups (P <0.05). The levels of TNF-а, CRP and sE-selectin in ECON group were significantly lower than those in CON group and EDI group compared with those in DI group, and the levels of serum IL-6 were significantly increased (P <0.05). Conclusion: Aerobic exercise can inhibit DMBA-induced breast cancer in rats and reduce chronic systemic inflammation may be one of the mechanisms.