急性肺损伤(acute lung injury,ALI)是由创伤、感染、休克等直接或间接因素导致的炎性反应综合征在肺部的表现,临床上病死率高达35%~40%~([1])。细胞凋亡(apoptosis),即程序化细胞死亡(programmed cell death,PCD),是机体炎症调控的重要机制,研究发现细胞凋亡在ALI的过程中发挥着重要作用。细胞凋亡的信号转导通路主要有死亡受体通路、线粒体通路和内质网通路,3条凋亡途 Acute lung injury (ALI) is a manifestation of inflammatory response syndrome caused by direct or indirect factors such as trauma, infection and shock in the lungs. The clinical mortality rate is as high as 35% -40% ). Apoptosis, programmed cell death (PCD), plays an important role in the regulation of inflammation in the body. It has been found that apoptosis plays an important role in ALI. Signal transduction pathways of apoptosis mainly include death receptor pathway, mitochondrial pathway and endoplasmic reticulum pathway, and three apoptosis pathway