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目的观察大鼠TLR4含量与NO、ET-1的关系,了解阿托伐他汀和二甲双胍对血管内皮功能的保护作用。方法分组:空白对照组;实验对照组;阿托伐他汀组;二甲双胍组;联合用药组,5周后测定ET-1、NO、TLR4含量。结果各组大鼠TLR4含量与ET-1成正相关,与NO成负相关。结论阿托伐他汀和二甲双胍可能通过降低TLR4含量保护血管内皮功能。
Objective To observe the relationship between TLR4 and NO, ET-1 in rats and to understand the protective effect of atorvastatin and metformin on endothelial function. Methods Groups: blank control group, experimental control group, atorvastatin group, metformin group, combined treatment group, the content of ET-1, NO and TLR4 were measured after 5 weeks. Results The content of TLR4 in each group was positively correlated with ET-1 and negatively correlated with NO. Conclusions Atorvastatin and metformin may protect the vascular endothelial function by decreasing the content of TLR4.