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目的研究人类白细胞抗原(human leukocyte antigen,HLA)HLA-DRB1等位基因多态性与急性淋巴细胞白血病(ALL)的相关性。方法采用Luminex流式技术-序列特异性寡核苷酸探针反向杂交(flow cytometry-sequencespecific oligonucleotide probe,FLOW-SSOP)方法对内蒙地区48例急性淋巴细胞白血病患者HLA-DRB1等位基因多态性进行分析,以北方地区健康群体资料作为正常对照。结果在急性淋巴细胞白血病中,DRB1*14XX等位基因频率较高,为5.352%;DRB1*13XX等位基因频率较低,为1.047%;白血病组和对照组比较DRB1*14XX等位基因频率高于对照组(P<0.05);DRB1*13XX等位基因频率低于对照组(4.428%,P<0.05);其它等位基因频率在两组之间差异无统计学意义。结论不同类型的白血病分别与不同型别的HLA基因有明显的相关性。
Objective To investigate the association of human leukocyte antigen (HLA) HLA-DRB1 alleles with acute lymphoblastic leukemia (ALL). Methods Flow cytometry-sequences specific oligonucleotide probe (FLOW-SSOP) was used to detect HLA-DRB1 alleles in 48 patients with acute lymphoblastic leukemia in Inner Mongolia. Sex analysis, healthy population data in the north as a normal control. Results In acute lymphoblastic leukemia, the frequency of DRB1 * 14XX allele was 5.352%, the frequency of DRB1 * 13XX allele was 1.047%, and the frequency of DRB1 * 14XX allele was higher in leukemia group and control group (P <0.05). The frequency of DRB1 * 13XX allele was lower than that of the control group (4.428%, P <0.05). There was no significant difference in other allele frequencies between the two groups. Conclusion Different types of leukemia have significant correlation with different types of HLA genes.