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高原脑水肿是急性高海拔病（高原病）的危重表现之一，其发病机制尚不完全清楚。本文复习了高原低氧环境下脑细胞通透性改变、脑血流量增加、脑毛细血管静水压升高、血脑屏障通透性的变化、交感活性增强、容量调节激素的变化、肾功能的改变、颅内高压和神经递质的变化等的发生机制及其在高原脑水肿发病机制所起的作用。
High altitude brain edema is one of the critical manifestations of acute high altitude disease (altitude sickness), the pathogenesis of which is not fully understood. This review reviewed the changes of brain cell permeability, increased cerebral blood flow, increased hydrostatic pressure in the brain capillary, changes in permeability of the blood-brain barrier, increased sympathetic activity, changes in capacity-regulated hormones, renal function Changes in intracranial hypertension and neurotransmitter changes and its mechanism of pathogenesis in the pathogenesis of high altitude brain edema.