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人微小病毒B19(简称B19病毒)是一种单链、线性DNA病毒,是学龄儿童传染性红斑(又称第五病)的病原体。妊娠期急性B19病毒感染的发生率约为1%~2%,在感染爆发流行时妊娠期妇女的感染率可上升至10%~([1])。由于B19病毒可以通过胎盘,孕妇感染B19病毒后可通过母胎垂直传播途径引起胎儿宫内感染。尽管大多数情况下胎儿宫内感染可自发缓解,不影响胎儿结局,但部分患者B19病毒宫内感染可导致胎儿水肿、死胎和自然流
Human parvovirus B19 (referred to as B19 virus) is a single-stranded, linear DNA virus that is the causative agent of infectious erythema (also known as fifth disease) in school-age children. The incidence of acute B19 virus infection during pregnancy is about 1% to 2%, and the infection rate in pregnant women can rise to 10% ~ ([1]) during the outbreak. As the B19 virus can pass through the placenta, pregnant women infected with B19 virus can cause fetal infection through the vertical transmission of the fetus. Although in most cases fetal infection can be spontaneous remission, does not affect the fetal outcome, but some patients with intrauterine infection of B19 virus can lead to fetal edema, stillbirth and natural flow