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氧代赖氨酸系我所抗菌素室从辽宁省大连地区土壤中分离得到的新种玫瑰录褐链霉菌(Streptomyces roseoviridofuscus n sp)所产生的抗菌素。经动物实验证明对多种实体瘤有效,本文继续报道以不同给药途径和给药方案对脑瘤-22小鼠的治疗作用。用氧代赖氨酸的总量为1～1.5g/kg,于按种后不同时间以腹腔、尾静脉、肌肉、口服给药,对脑瘤-22均有明显治疗作用,其抑制率为47～78％。氧代赖氨酸200～400 mg/kg静脉注射对狗的血象、肝、肾功能,心电图影响不明显,100 mg/kg剂量对猴也无毒性反应。以氚标记的氧代赖氨酸对实验小鼠进行研究,表明口服吸收良好。静脉注射或口服200mg/kg,均以肝放射性为高,瘤中放射性虽不高,但能维持48小时以上。放射性排出以肾脏为主,静脉注射后24小时从尿中排出约为63％。
Oxylysine is an antibiotic produced by a new strain of rose Streptomyces roseoviridofuscus n sp isolated from soil in Dalian, Liaoning Province, China. Animal experiments proved effective for a variety of solid tumors, the paper continued to report on the different routes of administration and dosing regimen on brain tumor -22 mice. With oxo-lysine in a total amount of 1 ~ 1.5g / kg, at different times according to the kind of intraperitoneal, tail vein, muscle, oral administration of brain tumor -22 have significant therapeutic effect, the inhibition rate 47 ~ 78%. Oxylysine 200 ~ 400 mg / kg intravenous injection of dog blood, liver, kidney function, ECG had no obvious effect, 100 mg / kg dose of non-toxic reaction to the monkey. Tritiated labeled L-lysine was studied in experimental mice, indicating good oral absorption. Intravenous or oral 200mg / kg, are high in liver radioactivity, tumor radioactivity is not high, but can maintain more than 48 hours. Radioactive discharge mainly to the kidneys, 24 hours after intravenous injection from the urine of about 63%.