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目的测定ACA在SLE中出现的频率及其在SLE中的临床意义。方法应用酶联免疫吸附试验(ELISA)对30例SLE患者血清中ACA进行检测,并以正常人血清作对照。结果 1正常人IgG、IgM、IgA型ACA的结合指数(BI)值分别为1.48±0.43、1.46±0.43和1.00±0.33.2.SLE组BI值:IgG-ACA、IgM—ACA、IgA-ACA分别为3.04±1.25、3.07±1.61、1.96±1.05,与正常组BI值比较差异均有显著性意义(P<0.05)。3.ACA与SLE患者部分临床表现如血小板减少、血管炎、肾脏病变、雷诺现象及实验室指标如低补体 C3有一定的相关关系。 4. ACA与抗核抗体(ANA)之间里直线相关,ANA分别与 IgG-ACA相关,r=0.912;与 IgM-ACA相关,r=0.870;与 IgA—ACA相关,r=0. 758。 P值均< 0. 01。结论 1. SLE组 ACA值显著高于正常对照组。 2. ACA与 SLE患者血管损害、 血小板减少等密切相关。 3.各型 ACA与 ANA存在直线相关关系,说明 ACA值可以作为评价 SLE病情严重程度的指标之一。
Objective To determine the frequency of ACA in SLE and its clinical significance in SLE. Methods Serum ACA in 30 patients with SLE was detected by enzyme - linked immunosorbent assay (ELISA), and normal human serum was used as control. Results 1 The binding index (BI) values of normal human IgG, IgM and IgA ACA were 1.48 ± 0.43, 1.46 ± 0.43 and 1.00 ± 0.33.2, respectively. SLE group BI values: IgG-ACA, IgM-ACA, IgA-ACA were 3.04 ± 1.25,3.07 ± 1.61,1.96 ± 1.05, compared with the normal group BI values were There was significant (P <0.05). 3. Some clinical manifestations of ACA and SLE patients such as thrombocytopenia, vasculitis, renal disease, Raynaud’s phenomenon and laboratory indicators such as low complement C3 have a certain correlation. 4. There was a linear correlation between ACA and antinuclear antibody (ANA), with ANA associated with IgG-ACA, r = 0.912, r = 0.870 associated with IgM-ACA, and r = 0 associated with IgA-ACA. 758. P values were <0. 01. Conclusion 1. The ACA value in SLE group was significantly higher than that in normal control group. 2. ACA and SLE patients with vascular damage, thrombocytopenia are closely related. 3. There was a linear correlation between ACA and ANA, indicating that ACA can be used as one of the indicators to evaluate the severity of SLE.