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目的测定ＡＣＡ在ＳＬＥ中出现的频率及其在ＳＬＥ中的临床意义。方法应用酶联免疫吸附试验（ＥＬＩＳＡ）对３０例ＳＬＥ患者血清中ＡＣＡ进行检测，并以正常人血清作对照。结果 １正常人ＩｇＧ、ＩｇＭ、ＩｇＡ型ＡＣＡ的结合指数（ＢＩ）值分别为１．４８±０．４３、１．４６±０．４３和１．００±０．３３．２．ＳＬＥ组ＢＩ值：ＩｇＧ－ＡＣＡ、ＩｇＭ—ＡＣＡ、ＩｇＡ－ＡＣＡ分别为３．０４±１．２５、３．０７±１．６１、１．９６±１．０５，与正常组ＢＩ值比较差异均有显著性意义（Ｐ＜０．０５）。３．ＡＣＡ与ＳＬＥ患者部分临床表现如血小板减少、血管炎、肾脏病变、雷诺现象及实验室指标如低补体 Ｃ３有一定的相关关系。 ４． ＡＣＡ与抗核抗体（ＡＮＡ）之间里直线相关，ＡＮＡ分别与 ＩｇＧ－ＡＣＡ相关，ｒ＝０．９１２；与 ＩｇＭ－ＡＣＡ相关，ｒ＝０．８７０；与 ＩｇＡ—ＡＣＡ相关，ｒ＝０． ７５８。 Ｐ值均＜ ０． ０１。结论 １． ＳＬＥ组 ＡＣＡ值显著高于正常对照组。 ２． ＡＣＡ与 ＳＬＥ患者血管损害、 血小板减少等密切相关。 ３．各型 ＡＣＡ与 ＡＮＡ存在直线相关关系，说明 ＡＣＡ值可以作为评价 ＳＬＥ病情严重程度的指标之一。
Objective To determine the frequency of ACA in SLE and its clinical significance in SLE. Methods Serum ACA in 30 patients with SLE was detected by enzyme - linked immunosorbent assay (ELISA), and normal human serum was used as control. Results 1 The binding index (BI) values of normal human IgG, IgM and IgA ACA were 1.48 ± 0.43, 1.46 ± 0.43 and 1.00 ± 0.33.2, respectively. SLE group BI values: IgG-ACA, IgM-ACA, IgA-ACA were 3.04 ± 1.25,3.07 ± 1.61,1.96 ± 1.05, compared with the normal group BI values were There was significant (P <0.05). 3. Some clinical manifestations of ACA and SLE patients such as thrombocytopenia, vasculitis, renal disease, Raynaud’s phenomenon and laboratory indicators such as low complement C3 have a certain correlation. 4. There was a linear correlation between ACA and antinuclear antibody (ANA), with ANA associated with IgG-ACA, r = 0.912, r = 0.870 associated with IgM-ACA, and r = 0 associated with IgA-ACA. 758. P values were <0. 01. Conclusion 1. The ACA value in SLE group was significantly higher than that in normal control group. 2. ACA and SLE patients with vascular damage, thrombocytopenia are closely related. 3. There was a linear correlation between ACA and ANA, indicating that ACA can be used as one of the indicators to evaluate the severity of SLE.