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目的比较初诊2型糖尿病患者使用胰岛素和单纯口服降糖药联合强化治疗对患者血糖、血脂、B细胞功能和胰岛素敏感性的影响。方法将62例空腹血糖(FBG)7.0～11.0mmol/L的初诊2型糖尿病患者随机分为2组,第1组(30例)实行单纯胰岛素治疗,第2组(32例)接受格列齐特和二甲双胍联合治疗,分别在诊断初和强化治疗3个月时行口服葡萄糖耐量实验(OGTT),并测定FBG、餐后血糖(PBG)、糖化血红蛋白(HBA1C)以及血脂。结果治疗后,患者的血糖、血脂及B细胞功能均明显改善;单纯胰岛素治疗组HBA1C降低更显著。结论3个月后2组治疗方案均可以改善初诊2型糖尿病患者糖脂代谢、B细胞功能及胰岛素敏感性,单纯使用胰岛素治疗方案使糖代谢异常的改善更明显。
Objective To compare the effects of insulin and oral hypoglycemic agents in newly diagnosed type 2 diabetic patients on blood glucose, blood lipid, B cell function and insulin sensitivity. Methods Sixty-two newly diagnosed type 2 diabetic patients with fasting blood glucose (FBG) of 7.0-11.0 mmol / L were randomly divided into two groups. Group 1 (30 cases) received insulin alone and group 2 (32 cases) received Gliclazide And metformin combined with oral glucose tolerance test (OGTT) at 3 months after initial diagnosis and intensive treatment. FBG, postprandial blood glucose (PBG), HbA1c and blood lipid were measured. Results After treatment, the patient’s blood glucose, blood lipids and B cell function were significantly improved; simple insulin treatment group HBA1C more significant reduction. Conclusion After 3 months, the two groups of treatment regimens could improve the glucose and lipid metabolism, B cell function and insulin sensitivity in the newly diagnosed type 2 diabetic patients. The improvement of glucose metabolism was more obvious with the simple insulin treatment.