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目的观察高压氧(HBO)联合腺苷钴胺注射液治疗带状疱疹后遗神经痛(PHN)的临床疗效。方法 76例PHN患者,随机分为观察组(36例)和对照组(40例)。对照组给予腺苷钴胺注射液治疗,观察组在对照组基础上辅以HBO治疗。比较两组临床疗效。结果对照组40例无脱落,全部完成治疗和随访,无不良反应;观察组有1例因行HBO引起明显的头晕停止治疗退出,其余35例完成治疗和随访,无明显不良反应。治疗20 d后观察组总有效率为82.86%,高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗结束2周后观察组总有效率为91.43%,高于对照组的70.00%,差异有统计学意义(P<0.05)。结论 HBO联合腺苷钴胺注射液治疗PHN安全、有效,能改善患者的生存质量,值得应用。
Objective To observe the clinical efficacy of hyperbaric oxygen (HBO) combined with adenosylcobalamin injection in the treatment of postherpetic neuralgia (PHN). Methods 76 patients with PHN were randomly divided into observation group (36 cases) and control group (40 cases). The control group was treated with adenosylcobalamin injection. The observation group was supplemented with HBO on the basis of the control group. The clinical efficacy of the two groups were compared. Results The control group of 40 cases without shedding, all completed the treatment and follow-up, no adverse reactions; 1 case of observation group due to HBO caused significant withdrawal dizziness treatment withdrawal, the remaining 35 cases completed the treatment and follow-up, no significant adverse reactions. After 20 days of treatment, the total effective rate of the observation group was 82.86%, which was higher than that of the control group (60.00%), the difference was statistically significant (P <0.05). After 2 weeks of treatment, the total effective rate of the observation group was 91.43%, which was higher than that of the control group (70.00%), the difference was statistically significant (P <0.05). Conclusion HBO combined with adenosylcobalamin injection in the treatment of PHN is safe and effective and can improve the quality of life of patients.