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目的 研究舒芬太尼用于术后患者自控静脉镇痛(PCIA)的效果及其对血浆a-内啡肽(a-EP)的影响.方法 45例胃肠外科全麻术后患者行自控静脉镇痛,随机均分为A组(舒芬太尼3μg/kg)、B组(舒芬太尼2μg/kg)及C组(芬太尼20 μg/kg).FCIA不给负荷量.记录术后0、4、8、12、24、48 h VAS评分、镇痛泵的按压次数、并发症和患者的满意度等;于麻醉前、术毕、术后24、48 h测定血浆a-EP含量.结果 三组镇痛、镇静满意,并发症发生率均低,差异无统计学意义.A、B组PCA按压次数显著少于C组,且A组低于B组(P<0.05);A组术后48 h β-EP含量明显低于C组和B组(P<0.05).结论 舒芬太尼PCIA安全有效,优于芬太尼.“,”Objective To investigate the clinical efficacy of postoperative patient-controlled intravenous analgesia(PCIA) with sufentanil and its onβ-endorphin. Methods Fourty-five patients underwent abdominal surgery were randomly divided into three groups with 15 cases each. The rnpatients in groups of A and B were given surentanil 3μg／kg and 2 μg／kg for PCIA，respectively，and those in group C fentanyl 20 μg/kg as the controls．No loading dose was administered in all groups．Visual analogue scale(VAS)and sedation score were recorded at 4 h,8 h,12 h,24 h and 48 h during PCIA. The times of PCA, complications and satisfactory degree were observed. Plasma level of a-endorphin was examined before and during PCIA. Results Analgesia and sedation were all satisfactory with lass side effects in all three groups .The number of PCA was in an order of group A
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