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乙型肝炎病毒(HBV)感染期间造成肝细胞损伤的原因一般认为不是病毒本身直接作用的结果,因为乙型肝炎表面抗原(HBsAg)阳性的健康带毒者肝内堆积有较多病毒颗粒,但无明显组织病理学改变。因而认为肝细胞损伤是机体对病毒的免疫反应所致。主要有两种免疫机制。①抗病毒免疫;②对肝组织的自身免疫。前者包括对病毒的体液免疫和细胞免疫,后者为对由病毒感染或其他因素触发的自身靶抗原的免疫反应。
The cause of hepatocellular injury during Hepatitis B virus (HBV) infection is generally not considered to be a direct result of the virus itself, as more HBsAg-positive healthy carriers accumulate in the liver with more virions No obvious histopathological changes. So that liver cell damage is caused by the body’s immune response to the virus. There are two main immune mechanisms. ① antiviral immunity; ② on the liver’s autoimmune. The former includes humoral and cellular immunity to viruses, the latter being an immune response to a self-target antigen that is triggered by a viral infection or other factors.