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目的:探讨围手术期实施免疫增强型肠内营养对大肠癌患者术后的营养状况及免疫功能的影响。方法:选择大肠癌患者69例均分为实验A组、实验B组和实验C组。实验A组术前及术后均接受免疫增强型肠内营养支持,实验B组术后接受免疫增强型肠内营养支持,实验C组术后接受常规肠内营养支持,于术前、术后第1、9天分别检测患者的营养指标、免疫功能和炎症反应指标。结果:术后第1天,实验A组血清白蛋白(ALB)、转铁蛋白(TRF)、CD4+、CD4/CD8明显高于实验B组和实验C组,白细胞介素6(IL-6)水平低于实验B组和实验C组。术后第9天,实验A组血清白蛋白(ALB)仍然显著高于实验B组和实验C组;A组、B组的转铁蛋白(TRF)、CD4+与CD4/CD8明显高于C组,白细胞介素6(IL-6)水平显著低于C组。以上组间比较差异有统计学意义(P<0.05或P<0.01)。结论:围手术期实施免疫增强型肠内营养能改善大肠癌患者的营养状况和手术创伤后的细胞免疫功能,减轻术后的炎症反应。
Objective: To investigate the effect of perioperative immune-enhanced enteral nutrition on nutritional status and immune function in patients with colorectal cancer after operation. Methods: 69 cases of patients with colorectal cancer were divided into experimental group A, experimental group B and experimental group C Group A received immunosuppressive enteral nutrition support before and after operation. Group B received immunosuppressive enteral nutrition after operation. Group C received conventional enteral nutrition after operation, On the first and ninth days, the patients’ nutrition indexes, immune function and inflammatory response indexes were detected respectively. Results: On the first day after operation, serum albumin (ALB), transferrin (TRF), CD4 + and CD4 / CD8 in group A were significantly higher than those in group B and C, and interleukin 6 (IL- The level is lower than the experimental group B and experimental group C Serum albumin (ALB) in experimental group A was still significantly higher than those in experimental group B and C on the 9th postoperative day. The levels of transferrin (TRF), CD4 + and CD4 / CD8 in groups A and B were significantly higher than those in group C , Interleukin 6 (IL-6) levels were significantly lower than the C group. The difference between the above groups was statistically significant (P <0.05 or P <0.01). Conclusion: Perioperative immunocompromised enteral nutrition can improve the nutritional status of patients with colorectal cancer and cellular immune function after trauma, and reduce postoperative inflammatory response.