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目的探讨卡马西平及氟羟强的松龙对三叉神经痛患者睡眠质量及情绪状态的影响。方法研究对象源于本院2014年11月—2015年11月收治的86例三叉神经痛患者,随机分为对照组和观察组各43例。对照组采用卡马西平治疗;观察组采用氟羟强的松龙治疗。统计两组患者治疗前后疼痛视觉模拟评分(visual analogue scale,VAS)、汉密顿抑郁量表(Hamilton depression scale,HAMD)和汉密顿焦虑量表(Hamilton anxiety scale,HAMA)评分,并以11点计分法对患者治疗前后睡眠质量进行评估,观察两组治疗效果和不良反应发生情况。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果对照组治疗总有效率为81.40%,观察组为95.35%,比较差异有统计学意义(P<0.05)。治疗后两组患者VAS和睡眠干扰评分[(4.16±1.39)、(3.12±2.12)分,(4.25±2.37)、(2.18±1.05)分]比较,差异均有统计学意义(均P<0.05)。治疗后两组患者HAMD和HAMA评分[(11.53±4.25)、(7.45±4.12)分,(13.37±4.34)、(6.23±3.38)分]比较,差异均有统计学意义(均P<0.05)。结论较卡马西平,氟羟强的松龙治疗三叉神经痛更有利于提高患者睡眠质量,改善情绪状态,疗效安全可靠。
Objective To investigate the effects of carbamazepine and prednisolone on sleep quality and emotional status in patients with trigeminal neuralgia. Methods The subjects were from 86 patients with trigeminal neuralgia admitted to our hospital from November 2014 to November 2015 and were randomly divided into control group and observation group of 43 cases. The control group was treated with carbamazepine. The observation group was treated with fluoxetine. The visual analogue scale (VAS), Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores of two groups before and after treatment were calculated. Point scoring method to evaluate the quality of sleep before and after treatment, the two groups observed the effect of treatment and adverse reactions. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of the control group was 81.40%, and the observation group was 95.35%, the difference was statistically significant (P <0.05). After treatment, the differences of VAS and sleep disturbance scores between the two groups were statistically significant (all P <0.05) (4.16 ± 1.39, 3.12 ± 2.12, 4.25 ± 2.37, 2.18 ± 1.05) ). After treatment, the differences of HAMD and HAMA score between the two groups were statistically significant (all P <0.05) ([11.53 ± 4.25], (7.45 ± 4.12), (13.37 ± 4.34), (6.23 ± 3.38) . Conclusion Compared with carbamazepine and prednisolone, the treatment of trigeminal neuralgia is more conducive to improve the quality of sleep and improve the emotional status, and the curative effect is safe and reliable.