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目的探讨小儿川崎病发病第1周、第2~3周血小板参数的变化和临床意义。方法对78例川崎病患儿(病例组)及78例同期体检健康儿童(对照组)取静脉全血用ADVIA2120全自动血液细胞分析仪测定血小板数(PLT)、血小板压积(PCT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)。对疾病组和对照组血小板参数分别进行比较,并对血小板各参数进行相关性分析。结果川崎病患儿发病第1周PLT、PCT明显高于对照组(P<0.05),PDW低于对照组(P<0.05),MPV与对照组比较差异无统计学意义;川崎病患儿发病第2~3周PLT、PCT明显高于对照组(P<0.05),MPV、PDW均低于对照组(P<0.05);川崎病发病第2~3周PLT、PCT高于川崎病发病第1周,川崎病发病第2~3周MPV、PDW低于川崎病发病第1周。川崎病患儿PLT与MPV、PDW呈负相关(r=-0.391;r=-0.362);PLT与PCT呈正相关(r=0.969);PCT与PDW呈负相关(r=-0.356);MPV与PCT、PDW无相关性(r=-0.207;r=0.226)。结论血小板参数变化对川崎病诊断有非常重要意义,并可作为判断患儿病情及指导临床治疗用药的指标。
Objective To investigate the changes and clinical significance of platelet parameters in children with Kawasaki disease at the first week and the second to third weeks. Methods Totally 78 cases of children with Kawasaki disease (case group) and 78 healthy children (control group) were enrolled in this study. Total venous blood samples were collected for determination of platelet count (PLT), platelet pressure (PCT), platelet count Mean volume (MPV), platelet volume distribution width (PDW). The platelet parameters of disease group and control group were compared respectively, and the correlation analysis of platelet parameters. Results In the first week after onset of Kawasaki disease, PLT and PCT were significantly higher than those in the control group (P <0.05), PDW was lower than that in the control group (P <0.05), and there was no significant difference between the MPV group and the control group The levels of PLT and PCT in the second to third week were significantly higher than those in the control group (P <0.05), while the MPV and PDW were lower than those in the control group (P <0.05) 1 week, Kawasaki disease incidence of 2 to 3 weeks MPV, PDW lower than the first week of Kawasaki disease. PLT was negatively correlated with PDW (r = -0.391; r = -0.362); PLT was positively correlated with PCT (r = 0.969); PCT was negatively correlated with PDW (r = -0.356) PCT, PDW no correlation (r = -0.207; r = 0.226). Conclusion The change of platelet parameters is very important for the diagnosis of Kawasaki disease, and can be used as an index to judge the condition of children and guide the clinical treatment.