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目的:观察益气化瘀胶囊联合西药治疗急性心肌梗死后早期心室重构的临床疗效。方法:选取80例患者作为研究对象,按照双盲随机原则分为对照组和观察组各40例,对照组采用常规西药治疗,观察组在对照组治疗基础上采用益气化瘀胶囊治疗,对比2组患者治疗前后白细胞计数(WBC)、C-反应蛋白(CRP)、左室射血分数(LVEF)的变化情况和疗效。结果:疗程结束后,观察组治疗总有效率为95.0%,明显优于对照组的80.0%,差异有统计学意义(P<0.05)。治疗2周、4周后,2组WBC、CRP均较治疗前降低,LVEF均较治疗前升高,差异均有统计学意义(P<0.05)。观察组WBC、CRP含量均低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05)。结论:采用益气化瘀胶囊联合西药治疗急性心肌梗死后早期心室重构患者,能够有效缓解机体炎性反应,改善患者的左室功能,抗心室重构作用显著,值得在临床推广使用。
Objective: To observe the clinical efficacy of Yiqi Huayu capsule combined with western medicine in treating early ventricular remodeling after acute myocardial infarction. Methods: Eighty patients were selected as study subjects. They were divided into control group and observation group according to the double-blind random principle. The control group was treated with conventional western medicine. The observation group was treated with Yiqi Huayu capsule on the basis of the control group. The changes of WBC, C-reactive protein (CRP) and left ventricular ejection fraction (LVEF) before and after treatment in two groups were compared. Results: After the treatment, the total effective rate of the observation group was 95.0%, which was significantly better than that of the control group (80.0%), the difference was statistically significant (P <0.05). After 2 weeks and 4 weeks of treatment, the WBC and CRP in both groups were lower than those before treatment, and the LVEF were higher than those before treatment (all P <0.05). The contents of WBC and CRP in the observation group were lower than those in the control group, and the LVEF in the observation group was higher than that in the control group (P <0.05). Conclusion: The Yiqi Huayu capsule combined with Western medicine in patients with early ventricular remodeling after acute myocardial infarction can effectively relieve the body inflammatory response and improve left ventricular function in patients with significant anti-ventricular remodeling, and worth in the clinical promotion and use.