应用多种形式的分子分散系统制备药物包含物已日益增多,不论其设计目的是为了提高生物利用度(例如用高分子聚乙二醇制成的灰黄霉素固体溶液已有供售)或是为产生缓释效果,产品的性能都希望达到完全分散的程度。为此,需要借助物理分析方法测定药物中结晶与分子分散状态的比例作为质量控制的指标。 The use of various forms of molecular dispersion systems to prepare pharmaceutical compositions has increased, whether designed to increase bioavailability (eg, griseofulvin solid solutions made from high molecular weight polyethylene glycols are already on sale) or Is to produce a sustained release effect, the performance of the products are all hope to achieve full dispersion. To this end, the need for physical analysis of the determination of drugs in the crystalline and molecular dispersion of the ratio as an indicator of quality control.