简史1966年Thienpont 等发表了关于合成驱虫剂四咪唑(tetramisole)的论文。1971年R-enoux 等发现四咪唑增加布鲁氏菌疫苗对小鼠的保护作用。此后即广泛开展了四咪唑及其对映体左旋咪唑(levamisole)对免疫系统影响的深入研究。化学左旋咪唑的化学结构如下图所示,它是四咪唑的左旋对映体,分子量为240.75,白色粉末状结晶,易溶于水,在酸性溶液中很稳定。 A Brief History In 1966, Thienpont et al. Published a paper on the synthesis of a tetramisole. 1971 R-enoux and other found that four imidazole increased Brucella vaccine in mice protective effect. Since then, extensive studies have been conducted on the effects of tetraimidazole and its enantiomer levamisole on the immune system. The chemical structure of levamisole is shown in the figure below. It is the levorotatory enantiomer of tetraimidazole with a molecular weight of 240.75. It is a white powdery crystal that is soluble in water and stable in acidic solution.