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布美他尼(丁尿胺)比其他利尿剂有更明显的优点,通常用于病理性的体液潴留.本文报道了9例水肿患儿(年龄6.3±8.0y,体重19.1±12.4kg,血浆白蛋白≥25g/1,Na~+＞126mEq/L,K~+＞3.0mEq/L,其中细菌性脓毒症4例,病毒性肺炎3例,呼吸衰竭2例)静注布美他尼0.1mg/(kg·次),2次/日后一天内的药效动力学和药代动力学.收集给药前1.5小时内尿液,测定基础尿排泄率和肌酸、Na~+、K~+、Cl~-浓度,静注后收集20ml尿液,治疗前和给药后0.083,0.25,1,2,4,6和12h收集血浆标本,每次1.5ml.血浆和尿液标本中Na~+、K~+、Cl~-和肌酸浓度用标准实验室方法测定,布美他尼浓度用HPLG法测定.
Bumetanide has more obvious advantages than other diuretics, and is usually used for pathological fluid retention. In this paper, 9 children with edema (age 6.3 ± 8.0y, body weight 19.1 ± 12.4kg, plasma Albumin ≥25g / 1, Na ~ +> 126mEq / L, K ~ +> 3.0mEq / L, including bacterial sepsis in 4 cases, viral pneumonia in 3 cases and respiratory failure in 2 cases) Pharmacodynamics and Pharmacokinetics in 0.1mg / (kg · min), 2 times / day in the following day Urines were collected within 1.5 hours before administration, and basal urinary excretion rate and creatine, Na +, K ~ +, Cl ~ - concentration, 20ml of urine was collected after intravenous injection, plasma samples were collected before treatment and at 0.083,0.25,1,2,4,6 and 12h after treatment, each time 1.5ml. Plasma and urine samples Na ~ +, K ~ +, Cl ~ - and Creatine concentrations were measured by standard laboratory methods, and the concentration of bumetanide was determined by the HPLG method.