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虽然,我们仍未理解甾体激素对靶细胞作用的全部细节,但已经肯定了激素在细胞中是通过与受体蛋白质分子非共价而又相当稳定地结合来实现它的效应的。〔图1〕概括了雌激素同靶细胞互相作用的一般模式。雌激素(E)可能由被动扩散作用进入细胞,与细胞质中可溶性受体蛋白结合。这种互相作用的发生是基
Although we have not yet understood the full details of the effect of steroid hormones on target cells, it has been established that hormones in cells are effecting their effect by binding non-covalently with the receptor protein molecules rather stably. Figure 1 summarizes the general pattern of estrogen interaction with target cells. Estrogen (E) may enter the cell by passive diffusion and bind to the soluble receptor protein in the cytoplasm. The occurrence of this interaction is based