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研究表明，血管紧张素转换酶抑制剂（ＡＣＥＩ）能够减少糖尿病肾病的尿蛋白、延缓肾小球硬化的发生［１］；然而血管紧张素Ⅱ受体１拮抗剂（ＡＴ１ＲＡ）对糖尿病肾病的作用尚不清楚。我们通过观察ＡＴＩＲＡ──缬纱坦（ｖａｌｓａｒｔａｎ）对糖尿病大鼠蛋白尿、血压及肾组
Studies have shown that angiotensin-converting enzyme inhibitor (ACEI) can reduce urinary protein in diabetic nephropathy and delay the occurrence of glomerulosclerosis [1]; however, the effect of angiotensin II receptor 1 antagonist (AT1RA) on diabetic nephropathy still not clear. We observed by ATIRA ─ ─ valsartan (valsartan) on proteinuria in diabetic rats, blood pressure and renal