目的　研究矽肺抗纤维化治疗的远期疗效。方法　对“八五”攻关课题“矽肺治疗措施及效果评价研究”(简称“八五”)中的 10 0例矽肺治疗病例 ,停药 2年后 ,根据病情分别采用汉防己甲素 (汉甲素 ) +羟基磷酸哌喹 (羟哌 )、汉甲素 +克矽平、柠檬酸铝 (柠铝 ) +羟哌进行全量复治、小剂量治疗和继续停药 3种临床方案观察 2年。对照组仍为“八五”对照组的 5 0例矽肺病例。结果　咳嗽、咯痰的治疗有效率各治疗组均高于对照组 ;胸痛及呼吸困难的治疗有效率“汉甲素 +克矽平”的全量组也高于对照组。临床症状综合评价显示 ,无论经“八五”治疗后停药观察或“九五”攻关课题“联合用药治疗矽肺效果及综合评价方法研究”(简称“九五”)进行复治的病例 ,绝大部分均病情稳定 ,各治疗方案均没有出现病情加重病例。“八五”治疗病例停药 2年后 ,X线胸片病变形态都有进展 ,好转率降为 0 ;再经 2年治疗 ,X线胸片疗效观察结果 :(1)“汉甲素 +羟哌”全量组的好转率升至 2 3.8% ,进展率由停药后的 71.4%降至 42 .9% ;维持量组好转率为4.8% ,进展率由 14.3%降至 9.5 % ;观察组的好转率稳定为 4.6 %。 (2 )“汉甲素 +克矽平”全量组的好转率升至 33.3% ,进展率由 6 6 .7%降至 33.3% ;维持量组稳定率由 83.3%降至 5 0 .0 % ,? Objective To study the long-term effect of silicosis anti-fibrosis treatment. Methods A total of 100 cases of silicosis treated in the “Eighth Five-Year Plan” research project of “Evaluation and Evaluation of Silicosis Treatment Measures and Effects” (referred to as the “Eighth Five-Year Plan”) were enrolled in this study. (P <0.05). The three clinical regimens were treated with piperacillin, melatonin, g-silicon, aluminum citrate and leuprolide for two consecutive years. The control group was still the 50 cases of silicosis cases in the “Eighth Five-Year” control group. Results The effective rate of cough and expectoration was higher in all treatment groups than in control group. The effective rate of treatment of chest pain and dyspnea was also higher in the full-dose group of “Han-Kao + Ke-Si-Ping”. The comprehensive evaluation of clinical symptoms showed that no matter the cases treated by retreatment after the “Eighth Five-year Plan” treatment or the “Ninth Five-Year” tackling key issue of “Study on the effect and comprehensive evaluation of silicosis in combination therapy” (referred to as the Ninth Five-year Plan) Most of the patients were in stable condition and none of the treatment regimens were exacerbated. Two years after the “Eighth Five-Year Plan” treatment, the pathological changes of X-ray showed progress and the rate of improvement was reduced to 0. After two years of treatment, the results of X-ray examination were as follows: (1) The rate of improvement in the full-dose oxycodone group rose to 23.8%, the rate of progress was reduced from 71.4% to 42.9% after discontinuation of treatment, the rate of improvement was 4.8% and the rate of progress was reduced from 14.3% to 9.5% The turnover rate of the group stabilized at 4.6%. (2) The turnover rate of the “Han-kai-kai + Ke-xi-ping” group rose to 33.3% and the progress rate dropped from 6.67% to 33.3%; the stability of the maintenance volume group decreased from 83.3% to 50.0% ,?