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为了从已治甲亢患者中早期检出亚临床型甲低患者，我们观察了４４例治疗后甲亢患者静注ＴＲＨ前后血清ＴＳＨ、ＴＴ３、ＴＴ４、ＦＴ４的变化及其相互关系。结果发现临床甲低患者的血清ＴＴ３均值仍在正常范围，而ＴＴ４、ＦＴ４均值低于正常值；亚临床及临床甲低组在静注ＴＲＨ后３０ｍｉｎ，ＴＳＨ平均增值（△ＴＳＨ）分别为３１９１μＩＵ／ｍｌ和４９５０μＩＵ／ｍｌ，显著高于甲功正常组（其平均ＴＳＨ为６３２μＩＵ／ｍｌ），９０ｍｉｎ后ＴＳＨ明显下降，其平均值分别为１８５１μＩＵ／ｍｌ和４３９０μＩＵ／ｍｌ，但仍显著高于本组基础值，表现为明显的超常反应［１］；两组的基础ＴＴ４、ＦＴ４与ＴＳＨ值均呈负相关，ＦＴ４与静注ＴＲＨ后ＴＳＨ增值亦呈负相关。提示：诊断临床甲低，ＴＴ４和ＦＴ４比ＴＴ３灵敏；ＴＲＨ兴奋试验可为亚临床甲低的早期诊断提供可靠而有力的实验室依据。
To detect subclinical hypothyroidism early in patients with hyperthyroidism, we observed the changes of TSH, TT3, TT4 and FT4 in 44 patients with hyperthyroidism before and after intravenous administration of TRH and their correlation. The results showed that the average serum TT3 in patients with clinical hypothyroidism was still in the normal range, but the average values of TT4 and FT4 were lower than those in normal hypothyroidism patients. The mean TSH (TSH) of subclinical and clinical hypothyroidism were 31% at 30 minutes after intravenous injection of TRH. 91μIU / ml and 4950μIU / ml, which were significantly higher than those in normal thyroid function group (mean TSH was 632μIU / ml). After 90min, the TSH decreased obviously, with average values of 1851μIU / ml and 4390μIU / ml, but still significantly higher than the baseline values, showing a significant abnormal response [1]; the two groups of basic TT4, FT4 and TSH values were negatively correlated, FT4 and TRH after intravenous infusion of TSH also showed a negative correlation. Hint: The clinical diagnosis of hypothyroidism, TT4 and TT4 sensitivity than TT3; TRH stimulation test for subclinical hypothyroidism early diagnosis provides a reliable and powerful laboratory evidence.