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目的探讨更昔洛韦联合喜炎平与单用更昔洛韦或喜炎平对小儿疱疹性咽峡炎的临床效果。方法选用符合诊断标准的疱疹性咽峡炎患儿311例,随机分为3组。更昔洛韦组106例,静脉滴注更昔洛韦3～5mg/kg,1次/d,疗程5～7d;喜炎平组100例,静脉滴注喜炎平2mg/kg,1次/d,疗程5～7d;联合组105例,静脉滴注更昔洛韦3～5mg/kg,合用喜炎平2mg/kg,1次/d,疗程3～5d。结果治疗后联合组总有效率、退热时间和疱疹消退时间均较另两组有显著性差异(P<0.01或P<0.05)。结论更昔洛韦联合喜炎平治疗柯萨奇A组病毒感染所致疱疹性咽峡炎,疗效好、起效快、安全、毒副作用小,值得临床推广。
Objective To investigate the clinical effect of ganciclovir combined with Xiyanping and ganciclovir alone or Xiyanping on herpes simplex angina in children. Methods 311 cases of herpes simplex gonorrhoeae who meet the diagnostic criteria were randomly divided into 3 groups. Ganciclovir group 106 cases, intravenous infusion of ganciclovir 3 ~ 5mg / kg, 1 / d, course of treatment 5 ~ 7d; Xiyanping 100 cases, intravenous infusion of Xiyanping 2mg / kg, 1 / d, course of treatment 5-7d; combination group of 105 cases, intravenous ganciclovir 3 ~ 5mg / kg, combined with Xiyanping 2mg / kg, 1 / d, course of treatment 3 ~ 5d. Results After treatment, the total effective rate, antipyretic time and herpes remission time in the combined group were significantly different from those in the other two groups (P <0.01 or P <0.05). Conclusions Ganciclovir combined with Xiyanping treatment of herpes angina caused by Coxsackie A virus infection has good curative effect, quick onset, safety and little toxic and side effects, which is worthy of clinical promotion.