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给Ｗｉｓｔａｒ大鼠灌服复方天棘胶囊溶液，剂量分别为４．０、２．０、０．８ｇ（胶囊）／ｋｇ，连续９０ｄ。结果表明，０．８ｇ（胶囊）ｋｇ组对幼年大鼠的体重增长有明显的促进作用，４．０、２．０、０．８ｇ（胶囊）／ｋｇ组对大鼠造血功能、肝功能和肾功能均无明显毒性作用；组织形态学结果表明，各给药组大鼠的心、肝、脾、肺、肾、胆等重要器官无毒性损害改变。提示大剂量、长期服用复方天棘胶囊无明显毒副作用，是一种毒性低、安全性较大的有效药物。
Wistar rats were fed with compound Tian-Jian capsule solution at doses of 4.0, 2.0, and 0.8 g (capsules)/kg for 90 days. The results showed that 0.8g (capsule) kg group had a significant role in promoting weight gain in juvenile rats, 4.0, 2.0, 0.8g (capsule) / kg group on hematopoietic function, liver function and Renal function had no obvious toxic effects; histomorphological results showed that there were no toxic damage changes in the heart, liver, spleen, lung, kidney, gallbladder and other important organs of the rats in each administration group. It is suggested that large-dose, long-term use of compound Tian-Jian capsules has no obvious toxic or side effects, and is an effective drug with low toxicity and high safety.