论文部分内容阅读
目的观察奥曲肽持续静脉泵入辅助治疗恶性肠梗阻的效果。方法将204例恶性肠梗阻患者随机分为观察组和对照组各102例。对照组采用基础治疗,观察组在对照组基础上加用奥曲肽泵入治疗。治疗后比较2组第4、6天胃液引流量、拔管率、生存期,比较2组非手术治疗失败需急症手术率、切口感染率、预防性造口率和肠瘘率。结果观察组患者在第4天、第6天的胃液引流量均少于对照组(P<0.05)。观察组拔管率为34.31%显著高于对照组的22.55%(P<0.05)。观察组患者随访的最长时间为33周,对照组随访的最长时间为32周,2组随访生存期差异有统计学意义(P<0.05)。观察组非手术治疗失败需急症手术率、切口感染率、预防性造口率、肠瘘率均低于对照组,差异均有统计学意义(P<0.05)。结论奥曲肽持续静脉泵入辅助治疗恶性肠梗阻的效果及预后较好,值得临床推广应用。
Objective To observe the effect of continuous intravenous injection of octreotide on malignant intestinal obstruction. Methods Totally 204 patients with malignant intestinal obstruction were randomly divided into observation group and control group with 102 cases each. The control group with the basic treatment, the observation group on the basis of the control group plus octreotide pump treatment. After treatment, the drainage volume, extubation rate and survival rate of gastric juice on the 4th and 6th day in two groups were compared. The emergency operation rate, incision infection rate, prophylactic stoma rate and intestinal fistula rate were compared between the two groups. Results In the observation group, the amount of gastric fluid drainage on day 4 and 6 was less than that of the control group (P <0.05). The rate of extubation in the observation group was 34.31%, which was significantly higher than that in the control group (22.55%, P <0.05). The longest duration of follow-up was 33 weeks in observation group and 32 weeks in control group, the difference was statistically significant (P <0.05). The non-surgical treatment of observation group required emergency surgery rate, incision infection rate, prophylactic stoma rate, intestinal fistula rate were lower than the control group, the difference was statistically significant (P <0.05). Conclusion Continuous injection of octreotide for adjuvant treatment of malignant intestinal obstruction has a good prognosis and is worthy of clinical application.