论文部分内容阅读
目的:探讨血浆置换(PE)术治疗35例重症系统性红斑狼疮的疗效。方法:采用新鲜血浆和生理盐水及706代血浆组成的置换液治疗35例重症系统性红斑狼疮患者,并辅助用一些常用药物进行治疗。以泼尼松、环磷酰胺常规药物治疗25例重症系统性红斑狼疮患者作对照。分析2组患者治疗前、后血清中ANA、dsD-NA、ESR、C3、CRP、BUN、Cr、IgG、IgA、IgM指标的变化及治疗有效率。结果:重症系统性红斑狼疮患者经PE治疗后,血清中的IgG、IgA、IgM、ANA、dsDNA、ESR、C3、CRP、BUN、Cr较血浆置换前明显降低,差异有统计学意义,患者临床症状明显改善;PE组的总有效率为97.1%,对照组的总有效率为64.0%,差异有统计学意义(P<0.05)。102次PE过程中发生7次不良反应,对症处理后好转。结论:PE治疗重症系统性红斑狼疮疗效肯定,起效快,短期疗效显著,安全性好。
Objective: To investigate the efficacy of plasma exchange (PE) in the treatment of 35 cases of severe systemic lupus erythematosus. Methods: 35 patients with severe systemic lupus erythematosus were treated with replacement fluid composed of fresh plasma and saline and 706 generations of plasma, and assisted with some commonly used drugs for treatment. To prednisone, cyclophosphamide conventional drug treatment of 25 cases of severe systemic lupus erythematosus patients as a control. The changes of serum ANA, dsD-NA, ESR, C3, CRP, BUN, Cr, IgG, IgA and IgM in the two groups before and after treatment were analyzed. Results: The levels of IgG, IgA, IgM, ANA, dsDNA, ESR, C3, CRP, BUN and Cr in serum of patients with severe systemic lupus erythematosus after PE treatment were significantly lower than those before plasma exchange. The difference was statistically significant. The total effective rate was 97.1% in PE group and 64.0% in control group, the difference was statistically significant (P <0.05). There were 7 adverse reactions in 102 PE courses, which improved after symptomatic treatment. Conclusion: PE treatment of severe systemic lupus erythematosus positive effect, rapid onset, short-term effect is significant, good safety.