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目的研究鞍山地区女性人乳头瘤病毒(HPV)感染的常见基因型,探讨其临床意义。方法采用核酸分子快速导流杂交基因技术对815例女性患者进行HPV分型,同期行病理组织学诊断,分为炎症组583例,湿疣组15例,CINI组89例,CINII组77例,CINIII组42例,宫颈癌组9例。结果鞍山地区女性最常见的HPV基因型依次为16、58、52、33、31,CINI组中依次为HPV16、58、52、31、33,CINII组中依次为HPV16、58、52、33、31,CINIII组中依次为HPV16、33、31、52、53,HPV16与宫颈病变的级别呈正相关(P<0.05)。结论鞍山地区女性宫颈病变的常见HPV基因亚型是16、58、52、33、31,HPV16致病性最强。
Objective To study the common genotypes of female human papillomavirus (HPV) infection in Anshan area and to explore its clinical significance. Methods HPV genotyping was performed in 815 female patients by rapid flow-through hybridization of nucleic acid molecules and pathological diagnosis was performed in the same period. There were 583 cases of inflammation, 15 cases of genital warts, 89 cases of CINI, 77 cases of CINII, Group 42 cases, cervical cancer group 9 cases. Results The most common HPV genotypes in Anshan women were 16,58,52,33,31, followed by HPV16,58,52,31,33 in CINI group, followed by HPV16,58,52,33 in CINII group, 31, CINIII group followed by HPV16,33,31,52,53, HPV16 and cervical lesions was positively correlated (P <0.05). Conclusion The common HPV gene subtypes of female cervical lesions in Anshan are 16, 58, 52, 33, and 31, and HPV16 is the most pathogenic.