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目的探讨代谢综合征及其组分对老年性耳聋的影响。方法 2013年6月-2014年8月,于哈尔滨市第九医院耳鼻喉科连续收集165例老年性耳聋患者作为病例组,选取202例听力正常者作为对照组,分别进行问卷调查、人体测量(身高、体重和腰围)、听力检测和实验室检查(血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白)。采用χ2检验、t检验和单因素分析及多因素Logistic回归分析进行数据处理。结果代谢综合征组分中,仅甘油三酯的异常比例病例组高于对照组,在调整前、调整后均与老年性耳聋有关,OR分别为1.69(95%CI 1.09~2.63)和1.96(95%CI 1.08~3.54);其他组分均与老年性耳聋无关联。另外,代谢综合征组分的所有各种组合中,甘油三酯与高密度脂蛋白组合、甘油三酯与血糖组合、甘油三酯与血压组合,在调整前、调整后均与老年性耳聋有关,调整后的OR分别为5.31(95%CI1.63~17.27)、2.66(95%CI 1.04~6.85)和2.09(95%CI 1.04~4.18)。而代谢综合征与老年性耳聋无统计学关联,调整前及调整后与老年性耳聋的OR分别为1.27(95%CI 0.83~1.94)和0.92(95%CI 0.54~1.57)。而按年龄分层,调整后OR分别为0.89(95%CI 0.44~1.82)和1.49(95%CI 0.67~3.30),仍无统计学关联。结论甘油三酯异常与老年性耳聋有关联,甘油三酯与高密度脂蛋白的组合、甘油三酯与血糖的组合、甘油三酯与血压的组合均与老年性耳聋有关联。
Objective To investigate the effects of metabolic syndrome and its components on senile deafness. Methods From June 2013 to August 2014, 165 cases of senile deafness were collected in the Department of Otolaryngology, the 9th Hospital of Harbin. A total of 202 hearing-impaired patients were selected as the control group. Questionnaire and anthropometry Height, weight and waist circumference), audiometry and laboratory tests (blood glucose, total cholesterol, triglycerides, HDL, LDL). Chi-square test, t-test and univariate analysis and multivariate Logistic regression analysis were used for data processing. Results Among the components of metabolic syndrome, only the proportion of triglyceride abnormalities was higher in the case group than in the control group, and both were related to senile deafness before and after adjustment, with ORs of 1.69 (95% CI 1.09-2.63) and 1.96 95% CI 1.08 ~ 3.54); other components are not associated with senile deafness. In addition, all combinations of components of the metabolic syndrome, triglycerides and high-density lipoprotein combinations, triglycerides and blood glucose combinations, triglycerides and blood pressure, before adjustment, after adjustment are associated with senile deafness The adjusted ORs were 5.31 (95% CI 1.63-17.27), 2.66 (95% CI 1.04-6.85) and 2.09 (95% CI 1.04-4.18), respectively. The metabolic syndrome and senile deafness no statistical correlation, pre-adjustment and after adjustment for senile deafness were 1.27 (95% CI 0.83 ~ 1.94) and 0.92 (95% CI 0.54 ~ 1.57). However, stratified by age, adjusted OR were 0.89 (95% CI 0.44-1.82) and 1.49 (95% CI 0.67-3.30), respectively. There was no statistical significance. Conclusion The abnormality of triglyceride is associated with senile deafness. The combination of triglyceride and high density lipoprotein, the combination of triglyceride and blood glucose, and the combination of triglyceride and blood pressure are all associated with senile deafness.