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目的:研究解毒酶GSTT1、GSTM1基因多态性与鼻咽癌遗传易感性的关系。方法:应用PCR技术检测鼻咽癌组和对照组人群GSTM1和GSTT1基因。结果:GSTM1和GSTT1基因缺失率在鼻咽癌组分别为62.5%(50/80)和63.75%(51/80),对照组分别为44.44%(32/72)和40.27%(29/72),两组比较,差异有统计学意义(P<0.01或P<0.05)。多因素Logistic回归分析:吸烟及GSTT1缺乏与鼻咽癌的发生有关。结论:广西柳州地区鼻咽癌高发,当地人GSTM1和GSTT1缺失为遗传易感因素,联合环境致癌物作用,成为鼻咽癌主要原因之一。
Objective: To study the relationship between detoxification enzyme GSTT1, GSTM1 gene polymorphism and genetic predisposition of nasopharyngeal carcinoma. Methods: The GSTM1 and GSTT1 genes were detected by PCR in nasopharyngeal carcinoma and control subjects. Results: The deletion rates of GSTM1 and GSTT1 were 62.5% (50/80) and 63.75% (51/80) in the NPC group and 44.44% (32/72) and 40.27% (29/72) in the control group, respectively , The difference between the two groups was statistically significant (P <0.01 or P <0.05). Multivariate logistic regression analysis: smoking and lack of GSTT1 were associated with the occurrence of nasopharyngeal carcinoma. CONCLUSION: The high incidence of nasopharyngeal carcinoma in Liuzhou of Guangxi Province and the loss of GSTM1 and GSTT1 loci are genetic predisposing factors. Combined with environmental carcinogens, it is one of the main causes of nasopharyngeal carcinoma.