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随着经济社会的发展,人民生活水平的提高,由饮入酒精所致的乙醇相关性疾病的发病率越来越高,乙醇可致肠黏膜屏障损伤,引起肠道的细菌、毒素或抗原等移位进入血液循环,最终可能导致内毒素血症甚至多脏器衰竭。乙醇致肠屏障损伤的病理机制日益受到关注。肠屏障是指肠道能防止肠腔内细菌、毒素、抗原等穿过肠黏膜进入血液循环的结构和功能的总和,从结构和功能上可分为机械屏障、生物屏障、免疫屏障和化学屏障。乙醇及其代谢产物
With the economic and social development, people’s living standards improve, the incidence of alcohol-related diseases caused by drinking alcohol is getting higher and higher, ethanol can cause intestinal mucosal barrier damage, causing intestinal bacteria, toxins or antigens Shifting into the bloodstream can eventually lead to endotoxemia or even multiple organ failure. The pathological mechanism of ethanol-induced intestinal barrier injury is receiving more and more attention. Intestinal barrier refers to the intestine to prevent intestinal tract bacteria, toxins, antigens and other intestinal mucosa through the blood circulation into the structure and function of the sum, from the structure and function can be divided into mechanical barriers, biological barriers, immune barriers and chemical barriers . Ethanol and its metabolites