A regional climate-ecosystem model system is developed in this study. It overcomes the weakness in traditional one-way coupling models and enables detailed description of interactive process between climate and natural ecosystem. It is applied to interaction study between monsoon climate and ecosystem in East Asia, with emphasis on future climate and ecosystem change scenario forced by doubled CO2. The climate tends to be warmer and wetter under doubled CO2 in Jianghuai and the Yangzi River valley, but it becomes warmer and drier in inland areas of northern and northwestern China. The largest changes and feedbacks between vegetation and climate occur in northern China. Northern inland ecosystems experience considerable degradation and desertification, indicating a marked sensitivity and vulnerability to climatic change. The strongest vegetation response to climate change occurs in northern China and the weakest in southern China. Vegetation feedbacks intensify warming and reduce drying due to increased CO2 during summer in northern China. Generally, vegetation-climate interactions are much stronger in northern China than in southern China.