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严重血小板减少可致小血管出血,临床表现为紫癜、粘膜出血和带来致命性大出血,尤其颅内出血。血小板输注疗法(PTT)可用来预防和制止血小板减少患者的出血。PTT 对骨髓衰竭致血小板减少的病人有效,可降低出血死亡率。血小板计数与出血程度有关,其阈值约为20×10~9/L。急性白血病强烈化疗时可作预防性 PTT。再障患者用 PTT 有产生血小板抗体的危险和进一步输注困难。在接受骨髓移植患者,PTT 更宜少用。免疫性血小板减少者血小板破坏大于生成,循环中血小板年轻而大,具代谢活性,出血危险性较小。根据血小板大小,可测出血小板容积,中数阈值为
Severe thrombocytopenia can cause small blood vessels bleeding, clinical manifestations of purpura, mucous membrane bleeding and fatal bleeding, especially intracranial hemorrhage. Platelet transfusion therapy (PTT) can be used to prevent and stop bleeding in patients with thrombocytopenia. PTT is effective in patients with thrombocytopenia caused by bone marrow failure, can reduce bleeding mortality. Platelet count and the degree of bleeding, the threshold is about 20 × 10 ~ 9 / L. Acute leukemia can be used as a preventive PTT during intensive chemotherapy. Patients with aplastic anemia with PTT have the risk of platelet antibodies and further infusion difficulties. In patients receiving bone marrow transplantation, PTT should be less used. Immune thrombocytopenia is greater than the generation of platelet destruction, circulating platelets young and large, with metabolic activity, less risk of bleeding. According to platelet size, platelet volume can be measured, the median threshold is