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目的观察和分析人乳头瘤病毒(HPV)检测情况,同时对其与感染妇女宫颈病变程度的关系进行探讨分析,以期为诊断、治疗和预后判断提供客观的理论依据。方法入选2010年1月-2014年1月在医院就诊的不同程度宫颈病变患者658例作为研究观察对象,将患者不同程度宫颈病变样本分为慢性宫颈炎、CIN I、CIN II、CIN III、乳头瘤样病变和宫颈癌6个组别,分别进行人乳头瘤病毒(HPV)基因分型检测。结果 HPV感染总例数为359例,总感染率为54.6%,其中宫颈癌感染率85.3%,HPV感染总例数为359例,总感染率为54.6%,其中宫颈癌感染率85.3%,顺位为第一,除与乳头瘤样病变感染率比较无差异外(字2ef=0.80,P>0.05),与其他组别比较,差异有统计学意义。感染率最低的为慢性宫颈炎占41.9%,除与慢性宫颈炎、CIN I感染率比较差异无统计学意义(字2 ab=2.01,P>0.05;字2bc=1.35,P>0.05)。高危感染中乳头瘤样病毒感染构成比最高为慢性宫颈炎占36.29%(90例),其次为宫颈癌27.02%(67例),乳头瘤样病变最低0.81%(2例);低危感染中感染乳头瘤样病毒最高为慢性宫颈炎55.22%(37例),宫颈癌感染构成比仅为1.49%(1例);混合感染中CIN I感染HPV的构成比最低为4.55%(2例),慢性宫颈炎和宫颈癌均为29.55%(13例)。在高危亚型中构成顺位排在前三的分别是其他31.87%,HPV16感染率为21.51%,HPV58占13.15%;低危感染中顺位排在第一和第二的分别是HPV 6(29.85%)、HPV 11(28.36%)。结论不同程度宫颈病变与HPV感染率有关,且与高危型感染有明显相关性,而乳头瘤样病变则可能与低危型感染有明显关系。
Objective To observe and analyze the detection of human papillomavirus (HPV), and to explore its relationship with the degree of cervical lesions in infected women, in order to provide an objective theoretical basis for diagnosis, treatment and prognosis. Methods A total of 658 cervical lesions were selected from January 2010 to January 2014 in our hospital as study objects. Cervical lesions of varying degrees were divided into chronic cervicitis, CIN I, CIN II, CIN III, Tumor-like lesions and cervical cancer six groups, respectively, for human papillomavirus (HPV) genotyping test. Results The total number of cases of HPV infection was 359 and the total infection rate was 54.6%. The infection rate of cervical cancer was 85.3%, the total number of HPV infection was 359, the total infection rate was 54.6%, and the infection rate of cervical cancer was 85.3% The difference was statistically significant compared with other groups except for the difference in infection rate with papillomatosis (word 2ef = 0.80, P> 0.05). The lowest infection rate was chronic cervicitis (41.9%). There was no significant difference in CIN I infection rate between chronic cervicitis and cervicitis (word 2 ab = 2.01, P> 0.05; word 2bc = 1.35, P> 0.05). The highest constitutional ratio of HPV infection in high-risk infection was 36.29% (90 cases) of chronic cervicitis, followed by 27.02% (67 cases) of cervical cancer and 0.81% (2 cases) of papillary tumor-like lesion in low-risk infection The infection rate of papillomavirus was 55.22% (37 cases) in chronic cervicitis and 1.49% (1 case) in cervical cancer. The lowest proportion of HPV infection in CIN I group was 4.55% (2 cases) Chronic cervicitis and cervical cancer were 29.55% (13 cases). Among the high risk subtypes, the top three rankings were 31.87%, HPV16 infection rate was 21.51% and HPV58 was 13.15%. In the low-risk infection, the first and second were HPV 6 ( 29.85%), HPV 11 (28.36%). Conclusions Cervical lesions of varying degrees are related to HPV infection rate and have obvious correlation with high-risk infection, while papillary tumor-like lesions may have a clear relationship with low-risk infection.