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目的:分析呼和浩特某三级甲等医院骨科门诊超说明书用药情况,探讨其与临床不良反应/事件的关系,为超说明书用药管理提供参考依据。方法:采用回顾性分析方法,分层随机抽取该院2015年1-12月骨科门诊处方,分类统计超说明书用药类型,结合循证医学报道分析超说明书用药可行性。汇总分析因超说明书用药诱发的不良反应/事件,与同期上报的不良反应发生率相比较。结果:该院骨科门诊超说明书处方比例为9.88%。在用药类型方面以超剂量(疗程)用药(57.42%)最多;在用药科室方面以骨科专家门诊超说明书用药比例(44.26%)最高。所有超说明书用药中仅有8.97%(32/357)有循证医学证据。该院可追踪的因超说明书用药诱发药品不良事件13例次,发生比例为4.76%(13/273)。结论:骨科门诊超说明书用药现象普遍存在,相关各方面应引起重视并加以管理规范,以减少不良事件发生,促进临床合理用药。
OBJECTIVE: To analyze the usage of hyper-instruction in Orthopedic Clinic of a Grade-III Hospitals in Hohhot to investigate its relationship with clinical adverse reactions / events, and to provide a reference for the management of hyper-manual medication. Methods: A retrospective analysis method was used to randomly stratify the orthopedic outpatient prescriptions from January to December, 2015 in the hospital. The types of prescriptions were categorized and statistically analyzed. A meta-analysis of adverse drug reactions / events induced by over-instruction manuals was compared with the rate of adverse events reported during the same period. Results: The hospital orthopedic outpatient super prescription prescription ratio was 9.88%. In the type of medication with overdose (medication) medication (57.42%) up; in the medication department to orthopedic specialist outpatient super instructions drug use ratio (44.26%) highest. Only 8.97% (32/357) of all the super instructions medication evidence-based medicine. In the hospital, 13 cases of drug-induced adverse drug events were induced following the instruction manual, with a rate of 4.76% (13/273). CONCLUSION: Over-description of the medication in orthopedic clinics is widespread. All relevant aspects should be given attention to and regulated in order to reduce the occurrence of adverse events and promote the rational use of clinical medicine.