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为探讨重组人生长激素（ｒｈ ＧＨ） 对胃结肠癌患者术后蛋白分解代谢的影响，以及使用ｒｈ ＧＨ 后能否改善肿瘤患者的免疫功能，减轻术后疲劳综合征（ＰＯＦ） ，将３８ 例行根治性切除并经病理学证实的肿瘤患者（ 胃癌２１ 例，结肠癌１７例） 分为对照组（ ｎ ＝ １８） 和ｒｈＧＨ 治疗组（ ｎ ＝ ２０） ，两组患者术后均给予早期腹腔联合灌注化疗和经中心静脉施行的全胃肠外营养（ｔｏｔａｌ ｐａｒｅｎｔｅｒａｌ ｎｕｔｒｉｔｉｏｎ ，ＴＰＮ） 支持，ｒｈＧＨ 组术后第１ ～６ 天９∶３０ ａ ｍ 皮下注射８ Ｕ ｒｈＧＨ。结果：对照组术后第５ 、１０ 天的血清白蛋白、前白蛋白、转铁蛋白和ＩｇＧ、ＩｇＡ、Ｉｇ Ｍ 、ＣＤ＋３ 、ＣＤ＋４ 及ＣＤ＋８ 水平均较术前明显下降（ Ｐ＜ ０ ．０１） ；ｒｈ ＧＨ 治疗组ＣＤ＋３ 、ＣＤ＋４ 及ＣＤ＋８ 水平术后第１０ 天较术前明显升高（ Ｐ＜ ０ ．０１） ，其余变化无统计学意义； 精神状态明显好于对照组。术后第１０ 天，对照组患者体重下降３ ～５ ｋｇ ，ｒｈＧＨ 组下降１ ～２ ｋｇ（ Ｐ＜ ０ ．０１） 。实验结果提示： 肿瘤患者在术后早期腹腔联合灌注化疗和ＴＰＮ 营养支持的前提下应用重组人生长激素，能通过增加蛋白合成以克服术后应
To investigate the effect of recombinant human growth hormone (rh GH) on postoperative protein catabolism in patients with gastric colon cancer, and whether the use of rh GH can improve the immune function of patients with cancer and reduce postoperative fatigue syndrome (POF), 38 cases will be studied. Tumor patients with radical resection and confirmed by pathology (21 cases of gastric cancer and 17 cases of colon cancer) were divided into control group (n = 18) and rhGH treatment group (n = 20). Both groups were given early postoperative abdominal cavity In combination with infusion chemotherapy and total parenteral nutrition (TPN) supported by central vein, 8 U rhGH was subcutaneously injected at 9:30 am from the 1st to the 6th day of the rhGH group. Results: The levels of serum albumin, prealbumin, transferrin and IgG, IgA, Ig M, CD+3, CD+4, and CD+8 on the 5th and 10th days postoperatively in the control group were significantly lower than before surgery (P<0.01). The levels of CD+3, CD+4, and CD+8 in the rh GH treatment group were significantly higher than those before surgery on the 10th day after surgery (P < 0.01). The rest of the changes were not statistically significant. The mental status was significantly better than that of the control group. On the 10th day after surgery, the control group lost 3 to 5 kg of body weight, and the rhGH group decreased by 1 to 2 kg (P<0.01). The experimental results suggest that the use of recombinant human growth hormone on the premise of early postoperative intraperitoneal combined perfusion chemotherapy and TPN nutritional support can increase the protein synthesis to overcome postoperative