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目的 :探讨尼尔雌醇替代治疗对绝经后妇女子宫肌瘤的影响。方法 :48例确诊为围绝经期综合征的绝经后子宫肌瘤患者 ,随机分为两组 ,2 2例用尼尔雌醇替代治疗 ,2 6例用谷维素口服 ,两组均加服钙尔奇 D。观察并比较两组治疗前及治疗后 3、6、9、1 2个月的子宫大小、肌瘤大小及子宫内膜厚度。结果 :在 1 2个月的疗程中 ,两组在子宫及肌瘤大小、子宫内膜厚度上 ,差异均无显著性意义 (P >0 .0 5)。结论 :尼尔雌醇短期治疗绝经后伴子宫肌瘤的围绝经期综合征患者 ,是安全、有效的
Objective: To investigate the effect of nylestriol replacement therapy on uterine fibroids in postmenopausal women. Methods: Forty-eight patients with postmenopausal uterine fibroids diagnosed as perimenopausal syndrome were randomly divided into two groups. Two of them were treated with nylestriol, twenty-six were orally administered with oryzanol, Odd D. The uterus size, fibroid size and endometrial thickness were observed and compared before treatment, 3,6,9,1,2 months after treatment. Results: There was no significant difference in the size of uterus, fibroids and endometrial thickness between the two groups during the course of 12 months (P> 0.05). CONCLUSIONS: Short-term treatment with nylestriol in patients with perimenopausal uterine fibroids is safe and effective