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目的研究五磨饮治疗脾虚气滞型功能性消化不良的机制。方法选取广州中医药大学附属清远中医院2013年2~12月收治的脾虚气滞型功能性消化不良患者120例,按就诊先后顺序分为治疗组和对照组,各60例,治疗组给予五磨饮中药配方颗粒,对照组给予多潘立酮治疗,两组疗程均为4周。观察临床疗效,检测患者胃动素及胃泌素含量。结果治疗组和对照组总有效率分别为93.3%和83.3%,差异有统计学意义(P<0.05);治疗组患者血浆胃动素[(376.5±92.8)pg/mL]和胃泌素[(58.8±13.9)pg/mL]含量显著升高(P<0.05);对照组患者血浆胃动素[(356.7±85.4)pg/mL]含量显著升高(P<0.05),有升高血清胃泌素[(48.7±12.4)pg/mL]含量的趋势,但差异无统计学意义(P>0.05)。结论五磨饮能够有效治疗脾虚气滞型功能性消化不良,促进胃动素和胃泌素分泌可能是其作用机制之一。
Objective To study the mechanism of Wu mill drink in treating functional dyspepsia of spleen deficiency type. Methods 120 cases of functional dyspepsia patients with spleen deficiency and Qi stagnation type treated in Qingyuan Hospital of Traditional Chinese Medicine affiliated to Guangzhou University of Chinese Medicine from January 2013 to December 2013 were divided into treatment group and control group, Grinding Chinese medicine formula particles, the control group to domperidone treatment, the two groups were 4 weeks course of treatment. Observed the clinical curative effect, detected motilin and gastrin content in patients. Results The total effective rates of the treatment group and the control group were 93.3% and 83.3%, respectively, with statistical significance (P <0.05). The levels of plasma motilin [(376.5 ± 92.8) pg / mL] (P <0.05). The content of plasma motilin (356.7 ± 85.4) pg / mL in the control group was significantly higher than that in the control group (P <0.05) (48.7 ± 12.4) pg / mL], but there was no significant difference between the two groups (P> 0.05). Conclusion Wu mill drink can effectively treat functional dyspepsia of qi stagnation type and promote the secretion of motilin and gastrin may be one of its mechanisms.