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细胞周期是指连续分裂的细胞从一次有丝分裂结束到完成下一次有丝分裂所经历的整个连续过程,主要经过G1、S、G2、M期4个阶段。最新研究表明,细胞周期素(cyclin)和细胞周期素依赖蛋白激酶(CKIs)是cyclin-CDKs复合物的抑制因子,主要起负性调控。CKIs基因家族按结构和功能的不同分两类:一类为Ink4(Inhibitor of CDK4),包括p15、p16、p18和p19,这些基因均具有4个回纹状重复序列。能特异性抑制CDK4-cyclinD和CDK6-cyclinD的磷酸化酶的活性;另一类为CIP/KIP(CDK-interacting pro-
Cell cycle refers to the continuous process of dividing cells from the end of one mitosis to the completion of the next mitosis, mainly through four stages of G1, S, G2 and M phases. Recent studies show that cyclin and cyclin-dependent protein kinases (CKIs) are inhibitors of the cyclin-CDKs complex and are mainly negatively regulated. The families of CKIs are divided into two groups according to their structure and function: one is Ink4 (Inhibitor of CDK4), which includes p15, p16, p18 and p19. These genes all have four gyrus repeats. Can specifically inhibit the phosphorylase activity of CDK4-cyclinD and CDK6-cyclinD; the other is CIP / KIP (CDK-interacting pro-