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目的:探讨幼年和成年期心理应激对成年支气管哮喘大鼠免疫功能的影响及其生理机制。方法:将32只Wistar幼年大鼠随机分为哮喘模型组(成年期制备哮喘模型)、成年应激哮喘组(成年时给予心理应激的哮喘大鼠)、幼年应激哮喘组(幼年时给予心理应激的哮喘大鼠)和正常对照组(n=8)。建立心理应激与哮喘大鼠模型,肺组织HE染色与白细胞亚群计数,放免法测定血清IL-4、皮质醇、肺泡灌洗液IgE及脑组织IL-1β含量。结果:束缚应激可加重哮喘动物气道炎症和多项免疫指标紊乱。幼年应激后幼年应激哮喘组血清皮质醇显著高于其他各组(P<0.01),哮喘造模结束后成年应激哮喘组大鼠中枢IL-1β和血清皮质醇含量升高,幼年应激哮喘组降低。结论:幼年与成年心理应激均加重了大鼠哮喘,但存在不同机制,HPA轴在这一过程中起了重要作用。
Objective: To investigate the effects of psychological stress in infancy and adulthood on immune function and its physiological mechanism in adult asthmatic rats. Methods: Thirty-two Wistar rats were randomly divided into four groups: asthma model group (adult model of asthma), adult stress asthma group (adult model of asthma), juvenile stress asthma group Mental stress asthma rats) and normal control group (n = 8). To establish a rat model of psychological stress and asthma, the HE staining and leukocyte subsets of lung tissue were counted. The levels of IL-4, cortisol, IgE and IL-1β in brain tissue were determined by radioimmunoassay. Results: Restrain stress can aggravate airway inflammation and a number of immune disorders in asthmatic animals. Juvenile stress juvenile stress asthma group serum cortisol was significantly higher than other groups (P <0.01), adult asthma adult asthma group rats central IL-1β and serum cortisol levels increased, juvenile should Asthma asthma group decreased. Conclusion: Both juvenile and adult psychological stress aggravate asthma in rats, but there are different mechanisms. The HPA axis plays an important role in this process.