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目的 探讨肿瘤特异性生长因子、甲胎蛋白、癌胚抗原、糖类癌抗原199、糖类癌抗原50联合检测对消化道恶性肿瘤的早期诊断价值.方法 将123例消化道恶性肿瘤患者设为恶性肿瘤组,69例消化道良性肿瘤患者设为良性肿瘤组,70名健康人群设为对照组.检测3组血清肿瘤特异性生长因子、甲胎蛋白、癌胚抗原、糖类癌抗原199、糖类癌抗原50水平.消化道恶性肿瘤早期患者取病理组织切片,做受试者工作曲线,以组织病理检测结果 为金标准,比较单项及联合检测的敏感性、特异性、准确度.结果 3组肿瘤特异性生长因子、甲胎蛋白、癌胚抗原、糖类癌抗原199、糖类癌抗原50水平比较差异有统计学意义(P＜0.01),恶性肿瘤组最高,对照组最低.肝癌患者甲胎蛋白水平最高,结直肠癌患者癌胚抗原水平最高,以结直肠癌、胰腺癌患者糖类癌抗原199、糖类癌抗原50水平最高.联合检测对消化道恶性肿瘤的敏感度、特异度、准确度均较高.结论 联合检测血清肿瘤特异性生长因子、甲胎蛋白、癌胚抗原、糖类癌抗原199、糖类癌抗原50水平能提高消化道恶性肿瘤早期检出率,减少漏诊率,值得推广应用.“,”Objective To investigate the combined detection of 2-TSGF,AFP, CEA,CA199 and CA50 in the early diagnosis of digestive tract malignant tumor. Methods 123 cases of malignant tumor of digestive tract were selected as the malignant tumor group, 69 cases of benign tumor of digestive tract were selected as the benign tumor group, 70 cases of healthy people were selected as control group. The 2-TSGF,AFP, CEA,CA199 and CA50 levels of the 3 groups were detected. Histopathologic slide of patients with digestive tract malignant tumor was taken and performed with ROC curve,with pathological results as gold standard, compare the sensitivity, specificity and accuracy of single and joint detection. Results There was statistic significance in the 2-TSGF,AFP, CEA,CA199 and CA50 levels among the three groups(P＜0.01), malignant tumor group was the highest, the control group was the lowest. The liver cancer patients had high AFP levels, colorectal cancer patients had high CEA levels, colorectal cancer and pancreatic cancer patients had high CA199 and CA50 levels. The combined detection had higher sensitivity, specificity and accuracy. Conclusion The combined detection of serum 2-TSGF,AFP, CEA, CA199 and CA50 levels can improve the detection rate of early malignant tumor of digestive tract,reduce the rate of misdiagnosis, which is worthy of popularization and application.