Objective: Small intestinal tumors(SBTs) were difficult to be discovered before surgery. The emergence of double-balloon enteroscopy(DBE) and capsule endoscopy(CE) have greatly improved the evaluation of SBTs and facilitated a more precise preoperative diagnosis. Yet little data exist in China regarding clinical efficacy of DBE and clinical characteristics of SBTs. The aim of our study was to clarify the clinical characteristics of SBTs and analyze the efficacy of DBE examination in the detection and diagnosis of SBTs. Methods: We retrospectively reviewed patients who underwent DBE in our hospital between June 2011 and July 2014. Patients who were diagnosed with SBTs by DBE were included in the study. Results: A total of 316 patients underwent 321 DBE procedures, 80(25.3%) of whom were suspected to have an SBT. And 59 of the 80 subjects were diagnosed with SBT finally. The majorities(59.3%, 35/59) of the patients diagnosed with SBT were males, whose average age was 61.8 years(SD ±11.0 years). DBE were frequently performed in patients with obscure gastrointestinal bleeding(66.1%), abdominal pain(16.9%). The common SBTs identified were: gastrointestinal stromal tumors(GISTs)(24/59, 40.7%), adenocarcinomas(13/59, 22.0%), lymphomas(6/59, 10.2%) and benign polyps(6/59, 10.2%). Jejunum had the highest detection rate(47.5%, 29/61). During the follow-up period(3 months to 3 years), 14 patients were submitted to chemotherapy and two patients died of tumor. Conclusion: The most high frequency type and location of SBTs detected in our hospital were different from western countries. DBE is a valuable and safe examination for SBTs. The emergence of double-balloon enteroscopy (DBE) and capsule endoscopy (CE) have greatly improved the evaluation of SBTs and facilitated a more precise preoperative diagnosis. Yet little data exist in China regarding clinical efficacy of DBE and clinical characteristics of SBTs. The aim of our study was to clarify the clinical characteristics of SBTs and analyze the efficacy of DBE examination in the detection and diagnosis of SBTs. Methods: We retrospectively reviewed patients who underwent DBE in our hospital between June 2011 and July 2014. Patients who were diagnosed with SBTs by DBE were included in the study. Results: A total of 316 patients underwent 321 DBE procedures, 80 (25.3%) of whom were suspected to have an SBT The 59 subjects of the patients diagnosed with SBT were males, whose average age was 61.8 years (SD ± 11.0 The common SBTs were identified as: gastrointestinal stromal tumors (GISTs) (24/59, 40.7%), adenocarcinomas (13 / Jejunum had the highest detection rate (47.5%, 29/61). During the follow-up period (3, 59, 22.0%), lymphomas (6/59, 10.2%) and benign polyps (6/59, months to 3 years), 14 patients were submitted to chemotherapy and two patients died of tumor. Conclusion: The most high frequency type and location of SBTs detected in our hospital were different from western countries.