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目的:评价奥曲肽联合泮托拉唑治疗肝硬化上消化道出血临床疗效。方法:我院2010年6月至2011年6月收治的肝硬化合并上消化道出血患者60例随机平分为对照组和实验组各30例,对照组单纯使用奥曲肽进行常规治疗,实验组在此基础上联合应用奥曲肽和泮托拉唑进行治疗,观察两组治疗效果及不良情况。结果:实验组平均止血时间为(16.5±3.8)h,总有效率为96.7%,心悸、恶心患者各1例;对照组平均止血时间为(23.4±5.2)h,总有效率为76.7%,心悸2例,恶心4例;两组差异对比具有统计学意义(P<0.05)。结论:联合应用奥曲肽与泮托拉唑治疗肝硬化上消化道出血,其疗效安全可靠,止血效果显著,值得临床应用及推广。
Objective: To evaluate the clinical efficacy of octreotide combined with pantoprazole in the treatment of upper gastrointestinal bleeding due to cirrhosis. Methods: From June 2010 to June 2011, 60 patients with cirrhosis and upper gastrointestinal hemorrhage admitted to our hospital were randomly divided into control group and experimental group, 30 cases in each group. The control group was treated with octreotide routinely. Based on the combination of octreotide and pantoprazole for treatment, the treatment effect and adverse effects were observed in both groups. Results: The average hemostasis time in the experimental group was (16.5 ± 3.8) h, the total effective rate was 96.7% and in the patients with palpitation and nausea, the mean hemostatic time was (23.4 ± 5.2) h in the control group, the total effective rate was 76.7% 2 cases of palpitations, 4 cases of nausea; the difference between the two groups was statistically significant (P <0.05). Conclusion: Combined application of octreotide and pantoprazole in the treatment of upper gastrointestinal hemorrhage caused by cirrhosis of the liver is safe, reliable and has a good hemostatic effect. It is worthy of clinical application and promotion.