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[目的]研究EphA2 mRNA和EphrinA1 mRNA在膀胱癌中的表达及其意义。[方法]应用逆转录—聚合酶链式反应(RT-PCR)检测50例膀胱癌冰冻标本中EphA2 mRNA和EphrinA1 mRNA的表达,比较各自mRNA与其蛋白表达的相关性及与临床病理特征的关系。[结果]膀胱癌组织中EphA2、EphrinA1 mRNA的表达均与组织学分级、淋巴结转移及TNM分期显著相关(P<0.05);EphA2和Ephri-nA1蛋白在膀胱癌的表达与各自mRNA的表达水平不完全一致。[结论]EphA2 mRNA和EphrinA1 mRNA阳性表达与膀胱癌的恶性行为相关。
[Objective] To study the expression of EphA2 mRNA and EphrinA1 mRNA in bladder cancer and its significance. [Methods] The expression of EphA2 mRNA and EphrinA1 mRNA in 50 cases of bladder cancer frozen samples were detected by reverse transcription-polymerase chain reaction (RT-PCR). The correlation between the expression of EphA2 mRNA and its protein and the clinicopathological characteristics were analyzed. [Results] The expressions of EphA2 and EphrinA1 mRNA in bladder cancer were significantly correlated with the histological grade, lymph node metastasis and TNM stage (P <0.05). The expressions of EphA2 and Ephri-nA1 in bladder cancer and their mRNA expression were not significantly different Exactly the same. [Conclusion] The positive expression of EphA2 mRNA and EphrinA1 mRNA is correlated with the malignant behavior of bladder cancer.