【摘 要】
：
Salidroside,the main active ingredient extracted from Rhodiola crenulata,has been shown to be neuroprotective in ischemic cerebral injury,but the underlying mec
【机 构】
：
Institute of Materia Medica,Fujian Academy of Traditional Chinese Medicine,Fujian University of Trad
【出 处】
：
Neural Regeneration Research
论文部分内容阅读
Salidroside,the main active ingredient extracted from Rhodiola crenulata,has been shown to be neuroprotective in ischemic cerebral injury,but the underlying mechanism for this neuroprotection is poorly understood.In the current study,the neuroprotective effect of salidroside on cerebral ischemia-induced oxidative stress and the role of the nuclear factor erythroid 2-related factor 2(Nrf2)pathway was investigated in a rat model of middle cerebral artery occlusion.Salidroside(30 mg/kg)reduced infarct size,improved neurological function and histological changes,increased activity of superoxide dismutase and glutathione-S-transferase,and reduced malon-dialdehyde levels after cerebral ischemia and reperfusion.Furthermore,salidroside apparently increased Nrf2 and heme oxygenase-1 expression.These results suggest that salidroside exerts its neuroprotective effect against cerebral ischemia through anti-oxidant mechanisms and that activation of the Nrf2 pathway is involved.The Nrf2/antioxidant response element pathway may become a new therapeutic target for the treatment of ischemic stroke.
其他文献
初见刘玉春,是在“环保产品推介会”上。发言者中,唯有他的身份属于“民”。那略带东北口音的发言,不“穿靴”。不“戴帽”。紧扣着自己的产品说。 等他走下台来,问几个能使
介绍了对甲苯磺酸和硫酸氢钾混合催化剂合成柠檬酸三丁酯的研究。考察了催化剂配比、催化剂用量、原料配比、反应温度和反应时间等因素对合成反应的影响,确定了最佳反应条件:
胎儿皮肤移植修复大面积皮肤缺损陈哨军＊张正新＊蔡福金＊我院曾对４例大面积皮肤缺损患者，行胎儿皮肤移植修复术，效果良好。本组男３例，女１例。年龄１３～３０岁。下肢３例，均为小腿环形皮肤缺损，肌肉、
尖端扭转型室速（torsadedepointes，TdP）是室性心动过速的一种特殊类型。发作对症状凶险，常引起阿-斯综合征，甚至导致死亡。近年来由于心电监护的广泛应用，TdP检出率日见增多，国内已
The Kovar alloy disks coated with Al film were anode bonded to the glass at temperatures of 513 ～ 713?K under the static voltage of 500?V. The kinetic
睡前喝酒有助于睡眠?来源:很多人都有这样的体会:晚上喝了酒之后能够很快入睡,因此认为喝酒有助于睡眠。真相:研究表明,酒精最初会使人昏沉欲睡,确实能缩短入睡时间,看似对睡
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
１６例小儿外伤后基底节区腔隙性梗塞的临床分析杨振铭杨波欧阳世杰蔡志谋我院自１９８９年１月～１９９３年６月收治小儿外伤后基底节区腔隙性梗塞１６例，报告如下。１病例与方法１．１病例：男１１例，女５例，年龄４个月～１１岁。坠落
幼儿石骨症并发右前臂骨折一例河南省偃师市人民医院（４７１９００）张猛，肖应德，李帅武，张有臣患者王某，女５岁，以平地摔倒致伤右前臂，患肢肿胀、疼痛、功能障碍１天，于１９９４年６月８日来诊。患者发育正常，体质中
老公嫌挣得少，跳槽到了一家食品企业。在食品企业上班，比在其他企业上班要多准备一个证：健康证。单位说，只要是区级以上的，给你健康证，去哪家医院体检都成。 老公到新单位后，就一直加班，半个多月了，还没休上一天。他就跟领导请了半天假去体检。到了取健康证的时间，他还在加班。你一个新员工，总不能再请假吧。好在医院离家比较近，我就去代领。对健康证，我以前没接触过，这回算是开了眼界了。 拿出老公身份证和我的